The Josephine Project aims to realize a novel class of high-temperature Josephson junctions (JJs) that behave as artificial neurons and synapses. This will dramatically enhance the impact of neuromorphics and multiply its projected applications (from artificial intelligence to autonomous vehicles and medical devices), which constitutes the long-term vision for the science we propose. Ultimately, we will make high-T_C quantum electronics a game-changer in the new generation of computing, communication, and sensing technologies.